The 6.7-magnitude earthquake has shut the island’s airport, power plants and train lines and caused dozens of landslides.
No casualties reported as 673 local residents evacuated away from Irrawaddy coast amid high waves, strong winds.
The second earthquake in a week has prompted an exodus of tourists while the death toll is expected to rise.
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According to experts, landslides in the area have become more significant in recent years.
Scores of aftershocks hampered rescue efforts as emergency personnel combed through collapsed buildings in search of survivors.